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2-methyl-ap-237 is a new research chemical, classifying the analgesic opioid. It is used in Southeast Asia as a powerful analgesic, with a variety of disorders. It has legal status in many countries. This product is very similar in action to morphine but is several times superior in potency, unlike morphine, they are strong and selective agonists of the μ-opioid receptor-MOR with a relatively low affinity for the δ-opioid receptor and κ-opioid receptor.
This product and all other synthetic opiates sold on this website are for research and legal applications. It is a designer drug with obvious physiological and psychoactive effects.
Side effects of the product are not known.
Storage conditions: in a cool and dry place. Terms 2-methyl-ap-237 , can last up to 2 years with proper storage conditions.
Chemical Composition of 2-Methyl-AP-237
|Formula||C18H26N2O • HCl|
2-Methyl-AP-237 is chemically known as 1-(2-methyl-4-(3- phenyl-2-propen-1-yl)-1-piperazinyl)-1-butanone (CAS 98608-61-8; hydrochloride salt 98608-59-4). 2-Methyl-AP- 237 is a methyl analogue of the opioid analgesic bucinnazine, which is also known as AP-237. Chemical syntheses of 2- methyl-AP-237 and other piperizino derivatives, such as AP- 237, para-methyl-AP-237, and AP-238, were originally patented in the 1980s. The chemical structure of 2-methyl- AP-237 is shown below:
Data obtained from pre-clinical studies demonstrate that 2-methyl-AP-237 exhibits mu-opioid receptor agonist pharmacological properties. According to the patent, an in vivo (in mice) study was conducted with 2-methyl-AP-237 and results indicated that at higher doses it produced analgesic effects in a hot plate assay. Data from in vitro studies showed that 2-methyl-AP-237, similar to fentanyl and morphine, binds to the mu-opioid receptors. Additionally, in an in vitro functional assay, 2-methyl-AP-237 activated mu-opioid receptors, albeit at a lower percentage of maximum stimulation when compared to fentanyl and morphine. These data demonstrate that 2-methyl-AP-237 has mu-opioid receptor agonist-like activity. It is well established that substances that act as mu-opioid receptor agonists have a high potential for addiction and can cause dose-dependent respiratory depression. In fact, abuse of 2-methyl-AP-237 has been associated with at least two fatalities and one non-fatal overdose in the United States.